Table I.
YC-1 improves sensorimotor and rota-rod motor performance tests following cerebral ischemia-reperfusion.
| Neurological behavioral score | Rota-rod performance | ||||||
|---|---|---|---|---|---|---|---|
| Variable | Weight loss (g) | Sensory | Motor | 28-point clinical scale | ACC (2–10 rpm/0-5 min) | FIX (5 rpm/min) | |
| Control, | N=7 | 4.8±1.1 | 3 (2.6–3.4) | 2 (1.6–2.4) | 15 (13.1–16.9) | 105.5±107.6 | 122.6±147.9 |
| YC-1 (5 mg/kg) | N=6 | 5.8±0.7 | 2 (1.7–2.3)a | 1 (0.6–1.4)a | 8 (7.5–8.5)a | – | – |
| YC-1 (25 mg/kg) | N=7 | 5.3±1.0 | 2 (1.5–2.5)a | 1 (0.7–1.3)a | 8 (6.5–9.5)a | 233.5±82.5a | 276.3±42.3a |
Data are presented as the mean ± standard deviation (weight and rota-road data) or as the median (neurological behavior score).
a
P<0.05 vs. control. ACC, accelerated speed; FIX, fixed speed.