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. 2018 May 31;18(2):1377–1386. doi: 10.3892/mmr.2018.9107

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Low KCNN3 expression is associated with DFS and OS in OC, as determined using KM survival plots. (A) Low KCNN3 mRNA expression was associated with shorter DFS in 489 patients with OC (TCGA ovarian cohort). (B) Low KCNN3 mRNA expression (probe: 205903_s_at) was associated with shorter OS in 1,656 patients (data from KM Plotter). Low KCNN3 protein expression was associated with (C) shorter OS and (D) DFS in 51 OC specimens. (E) Low KCNN3 mRNA expression was associated with shorter OS in 395 patients with OC whose CA 125 expression levels were in the lowest quartile (data from KM Plotter). mRNA expression values were dichotomized into high and low, using the median as a cutoff. Protein expression values were dichotomized into high and low, according to slide immunostaining scores. KCNN3, potassium calcium-activated channel subfamily N member 3; DFS, disease-free survival; OS, overall survival; OC, ovarian cancer; KM, Kaplan-Meier; CA 125, cancer antigen 125.