Table II.

Top 10 enriched GO biological process terms for DEGs between cerebral ischemia/reperfusion and sham control samples.

A, Top 10 enriched GO biological process terms for DEGs at 2 h post-reperfusion
GO ID	GO term	Count	%	P-value	Genes
GO:0030593	Neutrophil chemotaxis	5	15.63	5.65×10-6	CXCL1, CCL3, S100A8, CCL4, CCL7
GO:0032570	Response to progesterone	4	12.50	1.80×10-5	FOS, OXT, FOSB, GJB2
GO:0006954	Inflammatory response	7	21.88	2.24×10-5	CXCL1, CCL3, S100A8, CCL4, CCL7, CD14, IL1A
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	10	31.25	2.99×10-5	FOS, CCL3, EGR2, ATF3, EGR4, FOSB, NPAS4, JUNB, IL1A, CYR61
GO:0071356	Cellular response to tumor necrosis factor	5	15.63	3.59×10-5	LCN2, ZFP36, CCL3, CCL4, CCL7
GO:2000503	Positive regulation of natural killer cell chemotaxis	3	9.38	4.25×10-5	CCL3, CCL4, CCL7
GO:0006935	Chemotaxis	5	15.63	4.73×10-5	CCL3, S100A8, CCL4, CCL7, CYR61
GO:0051591	Response to cAMP	4	12.50	8.99×10-5	FOS, OXT, FOSB, JUNB
GO:0070098	Chemokine-mediated signaling pathway	4	12.50	1.13×10-4	CXCL1, CCL3, CCL4, CCL7
GO:0050729	Positive regulation of inflammatory response	4	12.50	1.69×10-4	CCL3, S100A8, CCL4, CCL7
B, Top 10 enriched GO biological process terms for DEGs at 8 h post-reperfusion
GO ID	GO term	Count	%	P-value	Genes
GO:0030593	Neutrophil chemotaxis	10	25.64	8.69×10-15	CXCL1, CCL12, CCL3, S100A8, LGALS3, CCL9, CCL4, CCL7, FCGR3, CCL17
GO:0002548	Monocyte chemotaxis	8	20.51	1.19×10-12	CCL12, CCL3, FLT1, LGALS3, CCL9, CCL4, CCL7, CCL17
GO:0070098	Chemokine-mediated signaling pathway	7	17.95	1.09×10-9	CXCL1, CCL12, CCL3, CCL9, CCL4, CCL7, CCL17
GO:0071356	Cellular response to tumor necrosis factor	8	20.51	1.83×10-9	LCN2, ZFP36, CCL12, CCL3, CCL9, CCL4, CCL7, CCL17
GO:0050729	Positive regulation of inflammatory response	7	17.95	2.52×10-9	CCL12, CCL3, S100A8, CCL9, TLR2, CCL4, CCL7
GO:0006935	Chemotaxis	8	20.51	3.01×10-9	CCL12, CCL3, FLT1, S100A8, CCL9, CCL4, CCL7, CCL17
GO:0071346	Cellular response to interferon-gamma	7	17.95	4.02×10-9	CCL12, CCL3, CCL9, CCL4, GBP2, CCL7, CCL17
GO:0048247	Lymphocyte chemotaxis	6	15.38	5.34×10-9	CCL12, CCL3, CCL9, CCL4, CCL7, CCL17
GO:0071347	Cellular response to interleukin-1	7	17.95	1.09×10-8	LCN2, CCL12, CCL3, CCL9, CCL4, CCL7, CCL17
GO:0006954	Inflammatory response	10	25.64	1.76×10-8	CXCL1, CCL12, CCL3, S100A8, CCL9, TLR2, CCL4, CCL7, CD14, CCL17
C, Top 10 enriched GO biological process terms for DEGs at 24 h post-reperfusion
GO ID	GO term	Count	%	P-value	Genes
GO:0006954	Inflammatory response	21	22.83	1.99×10-16	CXCL1, CCL3, CCL2, S100A8, CCL21C, S100A9, CCL9, TLR2, CCL21A, PF4, FPR2, IDO1, CCL4, CCL7, CXCL10, SLC11A1, CYBA, CCL12, CHIL3, CD14, SPP1
GO:0006955	Neutrophil chemotaxis	13	14.13	5.60×10-16	CXCL1, CCL3, CCL2, S100A8, LGALS3, CCL21C, S100A9, CCL21A, CCL9, CCL4, CCL7, CCL12, SPP1
GO:0006956	Chemokine-mediated signaling pathway	11	11.96	1.08×10-13	CXCL1, CCL12, CCL3, CCL2, CCL21C, CCL9, CCL21A, PF4, CCL4, CCL7, CXCL10
GO:0006957	Monocyte chemotaxis	9	9.78	1.54×10-11	CCL12, CCL3, CCL2, LGALS3, CCL21C, CCL9, CCL21A, CCL4, CCL7
GO:0006958	Positive regulation of inflammatory response	10	10.87	1.92×10-11	CCL12, CCL3, CCL2, S100A8, S100A9, CCL9, TGM2, TLR2, CCL4, CCL7
GO:0006959	Cellular response to tumor necrosis factor	11	11.96	1.39×10-10	LCN2, ZFP36, CCL12, CYBA, CCL3, CCL2, CCL21C, CCL9, CCL21A, CCL4, CCL7
GO:0006960	Cellular response to interleukin-1	10	10.87	1.76×10-10	LCN2, CCL12, CCL3, CCL2, CCL21C, CCL9, SAA3, CCL21A, CCL4, CCL7
GO:0006961	Lymphocyte chemotaxis	8	8.70	1.96×10-10	CCL12, CCL3, CCL2, CCL21C, CCL9, CCL21A, CCL4, CCL7
GO:0006962	Chemotaxis	11	11.96	2.80×10-10	CCL12, CCL3, CCL2, S100A8, S100A9, CCL9, PF4, FPR2, CCL4, CCL7, CXCL10
GO:0006963	Cellular response to interferon-gamma	9	9.78	1.33×10-9	CCL12, CCL3, CCL2, CCL21C, CCL9, CCL21A, CCL4, GBP2, CCL7

GO, Gene Ontology; DEGs, differentially expressed genes.