Table IV.

Enriched GO molecular function terms for DEGs between cerebral ischemia/reperfusion and sham control samples.

A, Enriched GO molecular function terms for DEGs at 2 h post-reperfusion
GO ID	GO term	Count	%	P-value	Genes
GO:0005125	Cytokine activity	6	18.75	2.48×10-5	CXCL1, FOS, CCL3, CCL4, CD14, IL1A
GO:0008009	Chemokine activity	4	12.50	6.79×10-5	FOS, CCL3, CCL4, CD14
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	6	18.75	2.84×10-4	FOS, EGR2, ATF3, FOSB, NPAS4, JUNB
GO:0001077	Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	5	15.63	9.82×10-4	FOS, EGR2, FOSB, NPAS4, JUNB
GO:0003690	Double-stranded DNA binding	3	9.38	2.13×10-2	FOS, FOSB, JUNB
GO:0003677	DNA binding	8	25.00	2.85×10-2	ZFP36, FOS, EGR2, ATF3, EGR4, FOSB, NPAS4, JUNB
B, Enriched GO molecular function terms for DEGs at 8 h post-reperfusion
GO ID	GO term	Count	%	P-value	Genes
GO:0008009	Chemokine activity	7	17.95	3.98×10-10	CXCL1, CCL12, CCL3, CCL9, CCL4, CCL7, CCL17
GO:0005125	Cytokine activity	8	20.51	1.54×10-7	CXCL1, CCL12, CCL3, CCL9, CCL4, CCL7, CCL17, TIMP1
GO:0048020	CCR chemokine receptor binding	4	10.26	2.14×10-5	CCL3, CCL9, CCL4, CCL17
C, Enriched GO molecular function terms for DEGs at 24 h post-reperfusion
GO ID	GO term	Count	%	P-value	Genes
GO:0008009	Chemokine activity	11	11.96	1.69×10-14	CXCL1, CCL12, CCL3, CCL2, CCL21C, CCL9, CCL21A, PF4, CCL4, CCL7, CXCL10
GO:0005125	Cytokine activity	12	13.04	4.78×10-9	CXCL1, CCL12, CCL3, CCL2, CCL9, PF4, CCL4, CCL7, SPP1, TIMP1, CXCL10, IL11
GO:0048020	CCR chemokine receptor binding	5	5.44	8.52×10-6	CCL3, CCL21C, CCL9, CCL21A, CCL4
GO:0031727	CCR2 chemokine receptor binding	3	3.26	1.30×10-4	CCL12, CCL2, CCL7
GO:0008201	Heparin binding	4	4.35	3.43×10-2	CCL2, PF4, CCL7, CXCL10
GO:0020037	Heme binding	4	4.35	4.94×10-2	HBA-A1, CYBA, HMOX1, IDO1

GO, Gene Ontology; DEGs, differentially expressed genes.