Table 2. Antibacterial activities of 3a–d and auranofin. Minimal inhibitory concentrations (MIC) are given in μM (standard deviations in brackets); MRSA = methicillin-resistant Staphylococcus aureus. As positive control antibiotics, amikacin (P. aeruginosa), linezolid (S. aureus) and ciprofloxacin (all other strains) have been used.
| Compound | MRSA RKI | MRSA DSM | E. faecium | E. coli | P. aeruginosa | A. baumannii | K. pneumoniae |
| 3a | >100 (0) | 79.0 (29.2) | >100 (0) | >100 (0) | >100 (0) | >100 (0) | >100 (0) |
| 3b | 12.7 (3.0) | 12.2 (8.0) | 70.0 (18.7) | >100 (0) | >100 (0) | >100 (0) | >100 (0) |
| 3c | 2.3 (1.2) | 1.7 (0.4) | 8.7 (0.5) | 47.7 (10.7) | 19.5 (6.1) | 48.7 (11.0) | 85.3 (26.9) |
| 3d | 16.6 (7.7) | 9.6 (3.4) | 25.5 (12.6) | >100 (0) | >100 (0) | >100 (0) | >100 (0) |
| Auranofin | 0.6 (0.7) | 0.4 (0.3) | 0.3 (0.3) | 45.7 (5.1) | >100 (44.1) | 55.0 (18.0) | 81.0 (48.0) |
| Antibiotic | 2.4 (1.4) | 4.7 (5.8) | 9.5 (2.0) | 0.1 (0) | 7.3 (1.5) | 0.9 (0.6) | 0.2 (0.1) |