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. 2018 Jun 22;18(2):2124–2132. doi: 10.3892/mmr.2018.9209

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Hypoxia-induced autophagy in RLE-6TN cells. Representative TEM images of the morphological and subcellular structure of different groups. (A) Untreated RLE-6TN cells were observed by TEM. The endoplasmic reticulum and mitochondria of control group were normal. (B and C) Swollen endoplasmic reticulum and mitochondria were observed in CoCl2 treatment group. In addition, autophagosomes in the cytoplasm also were observed in the CoCl2 treatment group. Red, blue and green arrowheads indicate the endoplasmic reticulum, mitochondria and autophagosomes, respectively. TEM, transmission electron microscopy. CoCl2, cobalt (II) chloride. Scale bar, 2 µm.