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. 2018 Jun 22;18(2):2124–2132. doi: 10.3892/mmr.2018.9209

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Inhibition of autophagy increased mitochondrial impairment in RLE-6TN cells. The ultrastructure of mitochondria of each group are presented. (A) Mitochondrial morphology was normal in the control group. (B) Swollen mitochondria were observed following CoCl2 treatment for 7 days in RLE-6TN cells. (C) Cells were treated with 3-MA and CoCl2 for 7 days. Compared with the control and CoCl2 groups, increased damage to mitochondrial morphology was observed. CoCl2, cobalt (II) chloride; 3-MA, 3-methyladenine. Magnification, ×8,000.