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. 2018 Jul 24;3(7):8226–8232. doi: 10.1021/acsomega.8b00850

Table 1. Sequences of siRNAs, N/P Ratio.

name S/ASa sequence (5′–3′)b N/P
siQL1 S GuucAGACCACuucAGcuudTdT  
  AS AAGCUGAAGUGGuCuGAAcdTdT  
siQL1[RGD] S GuucAGACCACuucAGcuudTdT  
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD  
siQL1[S5/RGD] S GuucAGACCACuucAGcuudTdT-S5-dT 0.42
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD  
siQL1[S10/RGD] S GuucAGACCACuucAGcuudTdT-S10-dT 0.77
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD  
siQL1[S15/RGD] S GuucAGACCACuucAGcuudTdT-S15-dT 1.03
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD  
siQL1[S15] S GuucAGACCACuucAGcuudTdT-S15-dT 1.05
  AS AAGCUGAAGUGGuCuGAAcdTdT  
Cy3-siQL1 S GuucAGACCACuucAGcuudTdT  
  AS AAGCUGAAGUGGuCuGAAcdTdT-Cy3  
Cy3-siQL1[RGD] S GuucAGACCACuucAGcuudTdT  
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD-Cy3  
Cy3-siQL1[S5/RGD] S GuucAGACCACuucAGcuudTdT-S5-dT 0.41
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD-Cy3  
Cy3-siQL1[S10/RGD] S GuucAGACCACuucAGcuudTdT-S10-dT 0.75
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD-Cy3  
Cy3-siQL1[S15/RGD] S GuucAGACCACuucAGcuudTdT-S15-dT 1.02
  AS AAGCUGAAGUGGuCuGAAcdTdT-RGD-Cy3  
Cy3-siQL1[S15] S GuucAGACCACuucAGcuudTdT-S15-dT 1.03
  AS AAGCUGAAGUGGuCuGAAcdTdT-Cy3  
a

S denotes sense strand and AS represents antisense strand.

b

Small letters indicate 2′-O-methyl RNA and dT indicates 2′-deoxythymidine.