Scheme 9. Synthesis of 2-Methylaminothiazole 78.
Reagents and conditions: (a) Br2, HBr 30% in AcOH, 75 °C, 4 h; (b) N-methylthiourea, EtOH, reflux temperature, 1 h; and (c) 4-morpholinoaniline, 1.25 M HCl in EtOH, n-BuOH, 180 °C, 16 h.
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