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. 2018 Jul 12;3(7):7809–7831. doi: 10.1021/acsomega.8b00668

Table 6. Influence of Substituents at the Pyridine-C2 Position.

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a

IC50 values are the mean of three experiments.

b

Percent inhibition at indicated concentration.

c

According to the ZINC patterns tool, compound 48m represents a potential pan-assay interference compound. However, this compound was synthesized as the intermediate for the preparation of inhibitors 48n–q. To estimate the impact of the amide moiety present in compounds 48n–q on the inhibition of the two kinases, the activities of 48m are listed in this table.