Table 8. Inhibitory Activity of Compound 44 on hERG Channels and on the Most Relevant CYP Isoforms.
| CYP450 inhibition [% inhibition at 10 μM] | |||||
|---|---|---|---|---|---|
| hERG inhibition [% inhibition at 10 μM] | 1A9 | 2C9 | 2C19 | 2D6 | 3A4 |
| 38.8 | 51.5 | 53.9 | 35.6 | 19.0 | 75.1 |
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