Table 1. Dissolution Results of IIIM-290, IIIM-290·HCl Salt and IIIM-290 Hippurate Form.
| Tmax (min) | Cmax (μg/mL) (mean ± SEM) | AUC0-–t (μg/mL min) (mean ± SEM) | AUC ratioa | |
|---|---|---|---|---|
| Dissolution in Water | ||||
| IIIM-290 | 30 | 6.93 ± 0.91 | 3557.23 ± 247.03 | 1 |
| IIIM-290·HCl | 60 | 15.42 ± 1.61 | 5240.98 ± 350.59 | 1.47 |
| IIIM-290 hippurate | 60 | 1.20 ± 0.13 | 1048.09 ± 92.58 | 0.29 |
| Dissolution in HCl Buffer (pH 1.2) | ||||
| IIIM-290 | 15 | 16.06 ± 0.49 | 2102.46 ± 80.09 | 1 |
| IIIM-290·HCl | 30 | 19.51 ± 0.09 | 2223.07 ± 81.96 | 1.1 |
| IIIM-290 hippurate | 30 | 14.11 ± 0.48 | 1789.91 ± 78.19 | 0.86 |
| Dissolution in Phosphate Buffer (pH 6.8) | ||||
| IIIM-290 | 15 | 9.52 ± 1.26 | 4898.69 ± 317.03 | 1 |
| IIIM-290·HCl | 15 | 13.58 ± 0.30 | 5896.10 ± 366.69 | 1.2 |
| IIIM-290 hippurate | 15 | 2.53 ± 0.32 | 2395.56 ± 173.57 | 0.49 |
a
[AUC0–t,sample]/[AUC0–t,IIIM-290]. SEM = standard error of the mean. Here, sample means IIIM-290·HCl or IIIM-290 hippurate form.