Fig 2.

Frequent missense mutations in JAK1, JAK3, STAT5B, and STAT3. Schematic shows protein domain structures of JAK3, JAK1, STAT5B, and STAT3. Black lines under the schematics show exon numbers above and amino acid numbers below; JAK3 exons are not shown because of differential splicing. Missense mutations are denoted by blue circles, with codon changes as shown. α, alpha helical domain, a DNA binding domain; FERM, the conserved domain named for its founding members (band 4.2, ezrin, radixin, and moesin); JH1, JAK homology domain 1, the functional kinase domain; JH2, JAK homology domain 2 (also known as the pseudokinase domain); SH2, Src homology domain 2; STAT-int, STAT interaction domain.