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. Author manuscript; available in PMC: 2018 Aug 2.
Published in final edited form as: Cell Rep. 2018 Jun 5;23(10):3031–3041. doi: 10.1016/j.celrep.2018.05.020

Figure 6. siRNA-Mediated Silencing of TERT Expression Decreases 5-FdU-Induced Activation of ATR and Signaling of Downstream Targets.

Figure 6

(A–D) The treatment of HCT 116 with 5-FdU results in the activation of p53 (A and B) and phosphorylation of Chk1 (Ser317) (A and C) and RPA32 (S33) (A and D). Expression levels were quantified using the ratio of phospho-RPA (S33), phospho-Chk1 (Ser317), and p53 to actin following drug treatments. Bars represent the mean ± SEM (n = 3). p values were calculated using Student’s t test.