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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Nucl Med Biol. 2018 Jun 8;62-63:71–77. doi: 10.1016/j.nucmedbio.2018.06.001

TABLE 1.

Mass spectrometry, IC50, and RP-HPLC data for [RGD-Glu-[DO3A]-6-Ahx-RM2] and [RGD-Glu-[[nat/86/90Y]Y-DO3A]-6-Ahx-RM2].

Molecular Formula [RGD-Glu-[DO3A]-6-Ahx-RM2] C109H163N29O29
Molecular Formula [RGD-Glu-[Y-DO3A]-6-Ahx-RM2] C109H160N29O29Y
Calculated molecular mass, [RGD-Glu-[DO3A]-6-Ahx-RM2] 2343.64 Da
Calculated molecular mass, [RGD-Glu-[[natY]Y-DO3A]-6-Ahx-RM2] 2429.56 Da
ESI-MS molecular mass, [RGD-Glu-[DO3A]-6-Ahx-RM2] 2344.86 Da
ESI-MS molecular mass, [RGD-Glu-[[natY]Y-DO3A]-6-Ahx-RM2] 2430.90 Da
[RGD-Glu-[DO3A]-6-Ahx-RM2], RP-HPLC tR 10.8 min
[RGD-Glu-[[natY]Y-DO3A]-6-Ahx-RM2], RP-HPLC tR 11.3 min
[RGD-Glu-[[86Y]Y-DO3A]-6-Ahx-RM2], RP-HPLC tR 11.2 min
[RGD-Glu-[[90Y]Y-DO3A]-6-Ahx-RM2], RP-HPLC tR 11.3 min
IC50, [RGD-Glu-[DO3A]-6-Ahx-RM2], PC-3 9.26±0.01 nM
IC50, [RGD-Glu-[[natY]Y-DO3A]-6-Ahx-RM2], PC-3 5.65±0.00 nM
IC50, [RGD-Glu-[DO3A]-6-Ahx-RM2], U87-MG 321±82.0 nM
IC50, [RGD-Glu-[[natY]Y-DO3A]-6-Ahx-RM2], U87-MG 346±5.30 nM