TABLE 2.
Biodistribution studies of [RGD-Glu-[[90Y]Y-DO3A]-6-Ahx-RM2] in PC-3 tumor-bearing SCID mice at 1, 4 and 24 h p.i. (%ID/g ± SD, n = 5). Tumor-to-non target tissue ratios for specific organs are in parentheses and italics (%ID/g, n = 5).
| 1 h | 4 h | 24 h | |
|---|---|---|---|
| Heart | 0.31±0.06 | 0.16±0.05 | 0.15±0.04 |
| Lung | 0.80±0.27 | 0.44±0.06 | 0.37±0.10 |
| Liver | 0.39±0.08 (22.31) | 0.35±0.07 (12.80) | 0.29±0.15 (18.21) |
| Kidneys | 2.36±0.49 (3.69) | 1.54±0.31 (2.91) | 0.89±0.21 (5.93) |
| Spleen | 1.36±0.25 | 1.07±0.18 | 1.21±0.23 |
| Stomach | 1.19±0.34 | 0.33±0.07 | 0.22±0.03 |
| S.Intestine | 1.41±0.32 | 0.39±0.09 | 0.34±0.07 |
| L.Intestine | 0.64±0.12 | 0.66±0.26 | 0.31±0.06 |
| Muscle | 0.22±0.06 (39.55) | 0.11±0.02 (40.73) | 0.10±0.03 (52.80) |
| Bone | 0.45±0.08 | 0.29±0.05 | 0.33±0.12 |
| Brain | 0.03±0.01 | 0.01±0.00 | 0.00±0.01 |
| Pancreas | 6.81±0.92 (1.28) | 0.55±0.12 (8.15) | 0.27±0.05 (19.56) |
| Blood* | 0.18±0.04 (48.33) | 0.01±0.00 (448.0) | 0.01±0.00 (528.0) |
| Urine* | 84.6±3.52 | 93.4±1.26 | 92.7±2.06 |
| Tumor | 8.70±0.35 | 4.48±0.31 | 5.28±0.12 |
*
Data presented as %ID