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. 2018 Jun 20;40(2):621–634. doi: 10.3892/or.2018.6515

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Copyright: © Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Western blot and RT-qPCR assays showed the downregulatory effect of TrKB siRNA on expression of BDNF and TrKB in AAT cells. Western blot and RT-qPCR assays were performed in HeLa and SiHa cells (control), AAT cells (model), AAT cells with negative TrKB treatment, and AAT cells with TrKB siRNA treatment. (A and B) For AAT cells derived from HeLa, protein levels of BDNF and TrKB were enhanced compared with corresponding HeLa cells, and attenuated in cells treated TrkB siRNA. (C) Relative mRNA levels of BDNF and TrKB were increased in AAT cells from model compared with corresponding HeLa cells, and decreased in AAT cells with TrKB siRNA treatment compared with AAT cells from model group. (D and E) Similarly, for AAT cells derived from SiHa, the protein levels of BDNF and TrKB were enhanced compared with corresponding SiHa cells, and attenuated in cells treated with TrkB siRNA. (F) Relative mRNA levels of BDNF and TrKB were increased in AAT cells (model group) compared with corresponding SiHa cells (control), and decreased in AAT cells with TrKB siRNA treatment compared with AAT cells (model group). *P<0.05, vs. control; ^#P<0.05, vs. siTrKB.