Table II.
Anticancer agents used in the present study.
| Compound | Target | Supplier | Purity, % |
|---|---|---|---|
| Nilotinib | ABL | Carbosynth | 100 |
| Ponatinib | ABL, Kit, Ret, FGFR | LC Laboratories | 100 |
| DCC-2036 | ABL, SRC, FLT3 | AdooQ BioScience | 100 |
| GDC-0068 | AKT | MedChemExpress | 100 |
| Ceritinib | ALK | Chemietek | 100 |
| Crizotinib | ALK, HGFR | LC Laboratories | 100 |
| Entrectinib | ALK, TrkA, B, and C, ROS1 | MedChemExpress | 100 |
| Bicalutamide | Androgen | Enzo Life Sciences | 100 |
| Pentostatin | Antimetabolite | Toront Research Chemicals | 100 |
| Elesclomol | Apoptosis | Selleck Chemicals | 100 |
| Aminoglutethimide | Aromatase | MP Biomedicals | 100 |
| Obatoclax | Bcl | LC Laboratories | 100 |
| Ibrutinib | Btk | MedChemExpress | 100 |
| Tacrolimus | Calcineurin | LC Laboratories | 100 |
| PAC-1 | Caspase | AdooQ BioScience | 100 |
| Dinaciclib | CDK | Cayman Chemical | 100 |
| PHA-793887 | CDK | AdooQ BioScience | 100 |
| Dexamethasone | Corticosteroid | Fujifilm Wako | 100 |
| Methotrexate | Dihydrofolate reductase | Fujifilm Wako | 100 |
| Leflunomide | Dihydroorotate dehydrogenase | TCI | 100 |
| Etoposide | DNA topoisomerase | Fujifilm Wako | 100 |
| Melphalan | DNA alkylation | Fujifilm Wako | 100 |
| Temozolomide | DNA alkylation | Fujifilm Wako | 100 |
| Decitabine | DNA demethylating | TCI | 100 |
| Fluorouracil | DNA synthesis | Fujifilm Wako | 100 |
| Mitomycin C | DNA synthesis | Fujifilm Wako | 100 |
| Carboplatin | DNA synthesis | TCI | 100 |
| Mycophenolic acid | DNA synthesis | TCI | 100 |
| Erlotinib | EGFR | Carbosynth | 100 |
| Afatinib | EGFR, HER2 | Selleck Chemicals | 100 |
| Lapatinib | EGFR, HER2 | LC Laboratories | 100 |
| Tamoxifen | Estrogen | Fujifilm Wako | 100 |
| GSK126 | EZH2 | AdooQ BioScience | 100 |
| AZD 4547 | FGFR | Active Biochem | 100 |
| Entinostat | HDAC | Carbosynth | 100 |
| Panobinostat | HDAC | Cayman Chemical | 98.19 |
| Belinostat | HDAC | Selleck Chemicals | 100 |
| PCI-34051 | HDAC | Selleck Chemicals | 98.28 |
| Tubastatin A | HDAC | Selleck Chemicals | 100 |
| Vismodegib | Hedgehog | LC Laboratories | 100 |
| Varlitinib | HER2, EGFR | Selleck Chemicals | 97.51 |
| Tivantinib | HGFR | MedChemExpress | 100 |
| Foretinib | HGFR, VEGFR, PDGFR, Kit, FLT3, Tie, Ron | Selleck Chemicals | 99.01 |
| Ganetespib | HSP90 | Selleck Chemicals | 100 |
| Alvespimycin | HSP90 | Selleck Chemicals | 100 |
| AGI-6780 | IDH2(R140Q) | MedChemExpress | 97.68 |
| BMS-754807 | IGF | Chemscene | 98.52 |
| OSI-906 | IGF | Chemietek | 100 |
| Ruxolitinib | JAK | Chemscene | 100 |
| AZD 6244 | MEK | LC Laboratories | 100 |
| Binimetinib | MEK | Active Biochem | 100 |
| Rapamycin | mTOR | LC Laboratories | 100 |
| Everolimus | mTOR | AdooQ BioScience | 97.97 |
| MLN-4924 | NAE | AdooQ BioScience | 100 |
| Olaparib | PARP | AdooQ BioScience | 100 |
| Tandutinib | PDGFR, Kit, FLT3 | LC Laboratories | 100 |
| Idelalisib | PI3K | AdooQ BioScience | 100 |
| NVP-BKM120 | PI3K | AdooQ BioScience | 100 |
| GDC-0980 | PI3K, mTOR | MedChemExpress | 98.63 |
| Volasertib | PLK | Chemietek | 100 |
| Carfilzomib | Proteasome | Chemietek | 100 |
| Bortezomib | Proteasome | AdooQ BioScience | 100 |
| Dabrafenib | BRAF | AdooQ BioScience | 100 |
| Vemurafenib | BRAF | ChemScene | 100 |
| RO-4929097 | Secretase | AdooQ BioScience | 100 |
| AZD 0530 | SRC, ABL | ChemScene | 100 |
| BX-795 | TBK, PDK, IKK | AdooQ BioScience | 97.34 |
| Lenalidomide | Thalidomide | AdooQ BioScience | 100 |
| Paclitaxel | Tubulin | TCI | 100 |
| Vindesine | Tubulin | Sigma-Aldrich | 100 |
| Nutlin-3 | Ubiquitin | KareBay Biochem | 100 |
| Brivanib | VEGFR, FGFR | AdooQ BioScience | 100 |
| Sunitinib | VEGFR, FGFR, PDGFR, Kit, FLT3 | Cayman Chemical | 96.85 |
| Regorafenib | VEGFR, Kit, Ret, FGFR, PDGFR | MedChemExpress | 100 |
Active Biochemicals Co., Ltd. (Kowloon, Hong Kong); AdooQ BioScience (Irvine, CA, USA); Carbosynth, Ltd. (Compton, UK); Cayman Chemical Company (Ann Arbor, MI, USA); Chemietek (Indianapolis, IN, USA); ChemScene (Monmouth Junction, NJ, USA); Enzo Life Sciences, Inc. (Farmingdale, NY, USA); Fujifilm Wako Pure Chemical, Ltd. (Osaka, Japan); KareBay Biochem, Inc. (Monmouth Junction, NJ, USA); LC Laboratories (Woburn, MA, USA); MedChemExpress (Monmouth Junction, NJ, USA); MP Biomedicals, LLC (Santa Ana, CA, USA); Selleck Chemicals (Houston, TX, USA); Sigma-Aldrich (Merck KGaA, Darmstadt, Germany); TCI Co., Ltd. (Tokyo, Japan); Toronto Research Chemicals (North York, ON, Canada).