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. 2018 Jun 14;40(2):659–668. doi: 10.3892/or.2018.6493

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Copyright: © Ke et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Prediction difference between NGS and US for high-risk thyroid nodules. (A and B) Case 1 and 2 were diagnosed via US with benign thyroid nodule, but pathological results revealed malignancy. US showed no typical features. However, both cases were PTC with BRAF mutation. (C and D) Case 3 and 4 had consistent results among NGS, US and pathological diagnosis. US demonstrated typically malignant features, including microcalcification and hypoechogenicity. Consistently, NGS also detected TC-related driver mutations, such as NRAS and TERT in case 3, and TP53 and TERT in case 4. NGS, next-generation sequencing; US, ultrasound; PTC, papillary thyroid cancer; TC, thyroid cancer.