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. 2018 May 24;40(2):693–703. doi: 10.3892/or.2018.6464

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Copyright: © Tamura et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Upregulation of NANOG expression in EC⁺ CSCs. cDNA microanalysis of (A) total gene expression, (B) transcription-related (including NANOG) gene expression, and (C) EMT-related gene expression in EC⁺ and EC⁻ CSCs. (A) Total gene expression differed between EC⁺ CSCs and EC⁻ CSCs. (B) NANOG expression was significantly upregulated in EC⁺ CSCs vs. EC⁻ CSCs. (C) Expression of genes related to EMT did not differ between EC⁺ CSCs and EC⁻ CSCs. (D) Immunofluorescence staining of a human colorectal cancer specimen. NANOG was expressed in the nucleus of CD44 and E-cadherin double-positive colorectal cancer cells (yellow arrow).