Figure 7.

Osthole sensitization of radiation in inhibition of cervical cancer cell viability by targeting multiple signaling pathways. Cervical cancer cells were grown and treated with osthole in combination with radiation. Combination treatment suppressed the protein expression of vimentin, N-cadherin, MMP-2 and MMP-9, induced the cleavage of pro-apoptotic caspase, inhibited the phosphorylation of γH2AX, IKKα and p65 proteins by ATM, and promoted the translocation of NF-κB from cell nuclei to cytoplasm. IR, irradiation; NF-κB, nuclear factor-κB; IKKα, inhibitor of NF-κB kinase α; p-, phosphorylated; ATM, ataxia telangiectasia mutated; MMP, matrix metalloproteinase.