Table II.
Association between SPAG4 expression and clinicopathological features.
| SPAG4 expression | ||||||
|---|---|---|---|---|---|---|
| Negative | Positive | |||||
| Clinicopathological data | Patients | − | + | ++ | +++ | P-value |
| Total | 46 | 5 | 9 | 18 | 14 | |
| Age (years) | 0.403 | |||||
| <60 | 22 | 4 | 4 | 8 | 6 | |
| >60 | 24 | 1 | 5 | 10 | 8 | |
| Histological type | 0.766 | |||||
| Squamous carcinoma | 15 | 1 | 4 | 5 | 5 | |
| Adenocarcinoma | 31 | 4 | 5 | 13 | 9 | |
| Tissue size (cm) | 0.447 | |||||
| D<3 | 16 | 2 | 4 | 6 | 4 | |
| D>3 | 30 | 3 | 5 | 12 | 10 | |
| Clinical grade | 0.008a | |||||
| I | 17 | 3 | 6 | 6 | 2 | |
| II | 16 | 2 | 3 | 5 | 6 | |
| III | 13 | 0 | 0 | 7 | 6 | |
| Differentiation degree | 0.014a | |||||
| Undifferentiated | 8 | 0 | 0 | 3 | 5 | |
| Poorly differentiated | 13 | 0 | 2 | 5 | 6 | |
| Moderately/well-differentiated | 25 | 5 | 7 | 10 | 3 | |
| Lymph node metastasis | 0.035a | |||||
| Yes | 30 | 2 | 4 | 13 | 11 | |
| No | 16 | 3 | 5 | 5 | 3 | |
a
P<0.05, significantly different. SPAG4, sperm-associated antigen 4.