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| ||||
| Compound | R | clog P (log D) | pKa (cpKa) | Nav1.3 IC50 (nM) |
| 22 |
|
4.5 (3.3) | 6.4 (6.6) | 13 |
| 24 |
|
3.7 (2.1) | 3.3 (4.3) | 13 |
| 25 |
|
3.9 (2.1) | (3.8) | 993 |
| 26 |
|
3.8 (1.8) | (3.9) | 374 |
| 27 |
|
3.8 (2.0) | 4.6 (4.7) | >3000 |
| 28 |
|
3.6 (2.4) | (4.1) | 1793 |
