Table 2. 5-HTR binding profile results (Ki, nM).
Comp. | 5-HT1A | 5-HT1B | 5-HT1E | 5-HT2A | 5-HT2B | 5-HT2C | 5-HT3 |
7 | 603 | 3406 | >10 000 | 2460 | 4.5 | 473 | >10 000 |
8 | 9389 | 8594 | >10 000 | 6794 | 569 | 986 | >10 000 |
11 | 5396 | 7596 | >10 000 | 5693 | 79.3 | 749 | >10 000 |
Clozapine | Nd a | Nd | Nd | 16.1 | Nd | Nd | Nd |
SB-206553 | Nd | Nd | Nd | Nd | 22.2 | Nd | Nd |
Ritanserin | Nd | Nd | Nd | Nd | Nd | 1.9 | Nd |
aNd; not determined.