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| Test | Comp. 7 |
| Effect of HSA | |
| 5-HT2B IC50 | 14.1 |
| 5-HT2B IC50 + 4% HSA | 18.7 |
| Stability in simulated fluids (t1/2, min) | |
| Gastric (pH 1.6) | 259 |
| Intestinal (pH 6.5) | >500 |
| Stability in human plasma (% remaining at 120 min) | 97.4 |
| CACO cell permeability | |
| P app, A → B (10–6 cm s–1) | 16.3 |
| P app, B → A (10–6 cm s–1) | 32.8 |
| Stability in rat liver microsomes (t1/2, min) | 179 |
| Cytotoxicity in HepG2 cells (IC50, μM) | >50 |
