Table 2. Cytotoxicity of selected compounds in HepG2 cells expressed as IC50 in comparison with MIC against Mtb H37Rv.
| No. | Mtb MIC [μM] a | HepG2 IC50 [μM] | Tested concentrations [μM] | SI (IC50/MIC) |
| 7f | 22.1 | >25 b | 0.1–100 | >1.1 |
| 8b | 9.4 | 24.79 | 1–1000 | 2.7 |
| 8d | 4.5 | >75b (834.9) c | 1–500 | >16.7 (186) d |
| 9b | 2.3 | >50 b | 1–500 | >21.5 |
| 9d | 4.5 | >25b (622.8) c | 0.1–100 | >5.6 (138) d |
| 9e | 4.1 | >25 a | 0.1–100 | >6.0 |
aMIC [μM] calculated as MIC [μg mL–1]/MW.
bMeasurement at higher concentrations not possible due to precipitation in the cell culture medium.
cValues in parentheses represent hypothetical IC50 values calculated from the trend of the inhibitory curve.
dSI calculated based on hypothetical IC50 values.