Table 4. Calculated physicochemical properties and the drug-likeness of the synthesized compounds.

Compd.	Predicted oral bioavailability						Drug-likeness
	HBA a	HBD b	M. W. c	clog P d	clog S e	TPSA f
5a	7	1	398.47	1.80	–2.39	77.64	5.04
5b	7	1	412.50	1.88	–2.02	77.64	4.36
5c	7	1	398.47	1.61	–1.75	77.64	4.73
5d	6	1	381.44	2.07	–3.26	72.71	2.74
5e	6	1	381.44	2.01	–3.23	72.71	2.74
5f	6	1	381.44	1.95	–3.23	72.71	2.74
5g	6	1	395.47	2.48	–3.37	72.71	2.83
5h	6	1	395.47	2.41	–3.34	72.71	2.83
5i	6	1	395.47	2.36	–3.34	72.71	2.83
5j	9	1	476.56	0.67	–2.81	111.78	6.10
5k	9	1	490.59	0.75	–2.43	111.78	5.52
5l	9	1	476.56	0.48	–2.16	111.78	5.82
5m	8	1	459.53	0.94	–3.67	106.85	4.13
5n	8	1	459.53	0.88	–3.65	106.85	3.97
5o	8	1	459.53	0.82	–3.23	106.85	2.74
5p	8	1	473.56	1.35	–3.79	106.85	4.26
5r	8	1	473.56	1.28	–3.76	106.85	4.09
5s	8	1	473.56	1.23	–3.76	106.85	2.57
10a	7	1	398.47	1.58	–2.39	77.64	5.04
10b	7	1	412.50	1.67	–2.02	77.64	4.36
10c	7	1	398.47	1.40	–1.75	77.64	4.73
10d	6	1	381.44	1.85	–3.26	72.71	2.74
10e	6	1	381.44	1.79	–3.23	72.71	2.74
10f	6	1	381.44	1.74	–3.23	72.71	2.74
10g	6	1	395.47	2.26	–3.37	72.71	2.83
10h	6	1	395.47	2.19	–3.34	72.71	2.83
10i	6	1	395.47	2.14	–3.34	72.71	2.83

^aNumber of hydrogen bond acceptors.

^bNumber of hydrogen bond donors.

^cMolecular weight.

^dCalculated lipophilicity.

^eSolubility parameter.

^fTopological polar surface area (Ų).