Table 2.

Fibrinogen, von Willebrand factor function and concentration

	Dextran-70 15 mL/kg (n = 6)	Albumin 25 mL/kg (n = 6)
Baseline
Fibrinogen (g/L)	0.85 ± 0.10	0.88 ± 0.17
vWF GP1b (kE/L)	0.70 ± 0.07	0.73 ± 0.03
vWF Ag (kE/L)	0.64 ± 0.05	0.71 ± 0.10
At completion of resuscitation
Fibrinogen delta (%)	−46 ± 4	−45 ± 4
vWF GP1b delta (%)	−22 ± 3	−21 ± 4
vWF Ag delta (%)	−25 ± 2*	−30 ± 5
At 240 min after resuscitation
Fibrinogen delta (%)	−46 ± 6	−40 ± 6
vWF GP1b delta (%)	−10 ± 5	−15 ± 8
vWF Ag delta (%)	−20 ± 3†	−28 ± 5

Reference intervals using the presently used methods in healthy humans are 2 g/L to 4 g/L for fibrinogen, 0.5 kE/L to 2.0 kE/L for vWF GP1b, and 0.60 kIE/L to 2.73 kIE/L for vWF Ag.

^*P < 0.05.

^†P < 0.01 versus Alb. (Student t test) Data are expressed as mean ± standard deviation.

GP1b indicates glycoprotein 1b; vWF Ag = von Willebrand factor antigen.