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. 2018 Jun 26;40(3):1251–1260. doi: 10.3892/or.2018.6525

Figure 2.

Figure 2.

Low expression of TRIM58 is correlated with poor prognosis in CRC patients. (A) TRIM58 expression in CRC tissues (n=161) was prominently inhibited compared with that in normal tissues (n=22) in a TCGA cohort. ***P<0.001, two-tailed Student's t-test. (B) Representative IHC staining for TRIM58 in human CRC cancer (lower panels) and adjacent normal colon tissues (upper panels). Scale bar, 100 µm. (C) Scatterplot of TRIM58 IHC scores in CRC and normal tissues. TRIM58 expression in a tissue microarray of 140 paired samples of CRC and normal colon tissues of patients was assessed by IHC. The receiver operating characteristic curve was used to define the cutoff. ***P<0.001, two-tailed Student's t-test. (D) Kaplan-Meier survival curves of overall survival duration based on TRIM58 expression in the CRC tissues of the testing cohorts. Survival curves show that patients with high TRIM58 expression survived significantly longer than those with low TRIM58 expression. P<0.0077, log-rank test. TRIM, tripartite motif protein; CRC, colorectal cancer; TCGA, The Cancer Genome Atlas.