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. 2018 Jun 25;40(3):1370–1378. doi: 10.3892/or.2018.6524

Figure 2.

Figure 2.

miR-195-5p regulates the multi-drug resistance of gastric cancer cells. The levels of miR-195-5p were analyzed in MNK28 cells transfected with (A) miR-195-5p mimic and (B) miR-195-5p inhibitor. The protein levels of P-gp, BCL-2 and MRP1 were measured by western blot analysis in MNK28 cells transfected with (C) miR-195-5p mimic and (D) miR-195-5p inhibitor. The chemosensitivities of 5-FU and L-OHP were determined by MTT in MNK28 cells transfected with (E) miR-195-5p mimic and (F) miR-195-5p inhibitor. *P<0.05 and **P<0.01, vs. control group. miR, microRNA; P-gp, P-glycoprotein; BCL-2, B-cell lymphoma 2; MRP1, Multi-drug resistance-associated protein 1; 5-FU, 5-fluorouracil; L-OHP, oxaliplatin; NC, negative control; 195m, miR-195-5p mimic; NCI, negative control inhibitor; 195i, miR-195-5p inhibitor.