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. 2018 Jul 12;40(3):1390–1400. doi: 10.3892/or.2018.6568

Figure 1.

Figure 1.

Cytotoxicity and survival of CT26/tk-luc cells treated with tetrandrine (TET) and/or radiation. (A) Growth curves of CT26 and CT26/tk-luc cells in vitro. The cell doubling times were 14.6 and 15.3 h, respectively. (B) Tumor growth curve of C26/tk-luc tumor-bearing mice. The tumor doubling time was 4.07 days. (C) Cytotoxicity of TET in CT26/tk-luc cells. CT26/tk-luc cells were treated with various concentrations of TET for 3 h, then evaluated by clonogenic assay to determine the surviving fractions. (D) Survival curves of CT26/tk-luc cells treated with TET and radiation. CT26/tk-luc were treated with various radiation doses alone and 20 µM TET for 3 h, then combined with various radiation doses, and evaluated by clonogenic assay. The survival curve for radiation treatment alone is shown by (○), while combination treatment is shown by (●). Normalization of this survival curve is shown by (▲). Data are expressed as the mean ± standard error (*P<0.05).