Table 2. A direct comparison of RBA values to ERα and ERβ for the various biaryl selenophene compounds with a BSC in this work and the corresponding ones without a BSC studied previously38.
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| This work |
Biaryl selenophenes (without BSC) |
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| Entry | R | Compound | RBA |
RBA |
||
| ERα | ERβ | ERα | ERβ | |||
| 1 | H | 9a | 12.4 ± 0.42 | 1.02 ± 0.08 | 0.61 ± 0.034 | 2.87 ± 0.20 |
| 2 | 2-Me | 9b | 1.96 ± 0.11 | 0.58 ± 0.07 | 5.60 ± 0.43 | 11.1 ± 0.73 |
| 3 | 2-F | 9e | 6.89 ± 1.02 | 0.63 ± 0.09 | 5.90 ± 0.90 | 24.3 ± 0.52 |
| 4 | 2-Cl | 9f | 4.59 ± 0.35 | 23.6 ± 0.49 | 6.11 ± 0.05 | 12.7 ± 3.66 |
| 5 | H | 12a | 2.06 ± 0.09 | 5.92 ± 0.28 | 0.32 ± 0.04 | 2.01 ± 0.11 |
| 6 | 2-Me | 12d | 0.56 ± 0.06 | 10.02 ± 0.17 | 0.27 ± 0.06 | 6.70 ± 0.49 |
| 7 | 3-Me | 12e | 2.03 ± 0.23 | 5.92 ± 0.14 | 0.71 ± 0.09 | 0.62 ± 0.12 |
| 8 | 3-F | 12g | 4.32 ± 0.32 | 15.3 ± 0.29 | 0.58 ± 0.14 | 1.56 ± 0.23 |