Table 3. Drug-likeness of compounds evaluated by Lipinski's rule of five.
Target | Compound | MW | HBD | HBA | log P | N |
MELK | OTS167 | 487.43 | 2 | 6 | 5.20 | 1 |
TOPK | OTS514 | 364.46 | 4 | 4 | 4.49 | 0 |
OTS964 | 392.52 | 2 | 4 | 5.04 | 1 | |
TTK | TTK-27f | 516.57 | 3 | 8 | 3.16 | 1 |