Table 1. Screening of quinoides 1–5 and VEGFR2-TKIs 6–10 in HCC cell lines.

Compound	IC50 (μM) a
	Huh7	Hep3B	Mahlavu
1	7.0 ± 0.8	12.0 ± 1.7	18.3 ± 0.8
2a	8.0 ± 0.9	5.5 ± 1.8	14.5 ± 1.3
2b	5.5 ± 0.4	4.3 ± 0.7	11.6 ± 0.2
3	20.0 ± 1.7	17.4 ± 2.1	31.3 ± 0.3
4	10.6 ± 2.0	9.9 ± 2.3	11.3 ± 0.6
5	Ni	Ni	Ni
6	1.6 ± 0.8	1.5 ± 0.3	0.7 ± 0.4
7	2.8 ± 1.3	2.0 ± 0.9	3.0 ± 0.5
8	1.7 ± 0.7	2.1 ± 0.3	0.8 ± 0.5
9	1.5 ± 0.7	0.7 ± 0.1	1.2 ± 0.4
10	0.4 ± 0.3	0.9 ± 0.3	1.1 ± 0.7
DAPT	5.0 ± 1.2	5.0 ± 2.0	5.0 ± 1.5

^aExperiments were performed in triplicate; Ni: no growth inhibition.