Fig. 1. Plot of PDE2A pIC50 values vs. DGAT1 pIC50 values where each orange circle represents the data for a particular fragment in the MMSs. The line of unity is shown in black and the orthogonal regression line is shown in magenta. Compounds with additional data in the DGAT1 MMS are shown as blue stars and plotted on the regression line. The regression line can be used to make predictions of PDE2A activity for fragments that were screened in the DGAT1 assay as shown for the carboxylic acid fragment.
