Fig. 2. Plot of PDE2A pIC50 values vs. HCV pIC50 values where each orange circle represents the data for a particular fragment in the MMSs. The line of unity is shown in black and the orthogonal regression line is shown in magenta. Compounds with additional data in the HCV MMS are shown as blue stars and plotted on the orthogonal regression line. The location of the carboxylic acid fragment and its prediction in PDE2A is shown.
