Fig. 1. SCFSkp2 complex with proposed inhibitor binding sites. ICM-Skin representation of PDB: ; 2AST. Compounds C1 and C2 target the Skp2 (cyan) and phospho-p27 peptide (green) interface. 22d targets the Skp2 and Cks1 (purple) interface preventing assembly of these subunits. Compound #25 and compound A both target the interface of Skp2 and Skp1 (orange).
