Fig. 2. SCFSkp2 druggable pockets. ICM-Skin and ribbon representation of PDB: ; 2AST. Skp1 (orange), Cks1 (purple) and phospo-p27 (green) are shown as mesh while Skp2 is represented as a yellow ribbon structure. The Skp2–Cks1–p27 interface pocket (cyan) is the target site for C1 and C2. It is not certain if linichlorin A and gentian violet also target this site. This pocket exists at an interface between Skp2 and Cks1 when phospo-p27 is removed. The Skp2–Cks1 interface pocket (red) has been previously noted to be an unusually large pocket and is the target site for 22d and NSC689857. It is also not certain if linichlorin A and gentian violet also target this site. The Skp2–Skp1 interface with no pocket is indicated with an arrow and compound #25 and compound A target this region.
