Table 3.

Odds ratios for breast cancer among cancer patients who either have AML or breast cancer by the presence or absence of point mutations in driver genes that either are, or are not, regulated by E2-ESR1.

	AML		Breast Cancer		Odds Ratio	P Value	95% Confidence Interval
	Number	(%)	Number	(%)
No mutations in regulated genes*	228	(16.3)	8	(1.7)	1.0‡
At least one mutation in regulated genes*	1,175	(83.7)	470	(98.3)	11.4	2.9×10−22	6.0 ‒ 25
Total	1,403	(100)	478	(100)
No mutations in unregulated genes†	419	(29.9)	330	(69.0)	1.0‡
At least one mutation in unregulated genes†	984	(70.1)	148	(31.0)	0.191	3.4×10−51	0.15 ‒ 0.24
Total	1,403	(100)	478	(100)
At least one mutation in unregulated genes†	984		148		1.0‡
At least one mutation in regulated genes*	1,175		470		22.4	2.4×10−17	11 ‒ 46

^*Genes regulated by E2-ESR1

^†Genes not regulated by E2-ESR1

^‡Denominator of following odds ratio