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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Cancer Prev Res (Phila). 2018 Mar 30;11(8):441–450. doi: 10.1158/1940-6207.CAPR-17-0419

TABLE 3.

Current Obstacles and Solutions for Chemopreventive Natural Compounds in HNSCC

Natural Compound Obstacles Current
Solutions		 Source
Vitamin A toxicity In combination, analogs, bioadjuvant (6–8,11–13)
Curcumin bioavailability analogs, bioadjuvant, liposomal, nanoparticles, phospholipid complex, in combination (4,5,15–17,21,23)
Isothiocyanate lack of studies specific to HNSCC In combination, analogs (37)
Green Tea bioavailability In combination, analogs (1,47,49)
Luteolin bioavailability, lack of studies specific to HNSCC Nanoparticles, in combination (100)
Resveratrol bioavailability, lack of studies specific to HNSCC Nanoparticles, in combination, bioadjuvant (61,70–72)
Genistein lack of studies specific to HNSCC In combination (3,83)
Lycopene lack of studies specific to HNSCC In combination, bioadjuvant (3,84)
Bitter Melon lack of studies specific to HNSCC Early stages of investigation (93–95)
Withaferin A lack of studies specific to HNSCC Early stages of investigation (96)
Guggulsterone lack of studies specific to HNSCC Early stages of investigation (97)