TABLE 3.
Natural Compound | Obstacles | Current Solutions |
Source |
---|---|---|---|
Vitamin A | toxicity | In combination, analogs, bioadjuvant | (6–8,11–13) |
Curcumin | bioavailability | analogs, bioadjuvant, liposomal, nanoparticles, phospholipid complex, in combination | (4,5,15–17,21,23) |
Isothiocyanate | lack of studies specific to HNSCC | In combination, analogs | (37) |
Green Tea | bioavailability | In combination, analogs | (1,47,49) |
Luteolin | bioavailability, lack of studies specific to HNSCC | Nanoparticles, in combination | (100) |
Resveratrol | bioavailability, lack of studies specific to HNSCC | Nanoparticles, in combination, bioadjuvant | (61,70–72) |
Genistein | lack of studies specific to HNSCC | In combination | (3,83) |
Lycopene | lack of studies specific to HNSCC | In combination, bioadjuvant | (3,84) |
Bitter Melon | lack of studies specific to HNSCC | Early stages of investigation | (93–95) |
Withaferin A | lack of studies specific to HNSCC | Early stages of investigation | (96) |
Guggulsterone | lack of studies specific to HNSCC | Early stages of investigation | (97) |