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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Mol Cancer Res. 2018 May 14;16(8):1226–1240. doi: 10.1158/1541-7786.MCR-17-0406

Figure 4. Guadecitabine-induced demethylation in adipocytes.

Figure 4

(A). Adipocytes (n=2) were treated with guadecitabine (100nM, daily 3X) and Methyl-Capture sequencing (MC-seq) was performed. Heatmap of promoter methylation (FDR < 0.05) comparing control to guadecitabine-treated adipocytes. (B). Genomic context of differentially methylated regions (DMRs) as determined by MethylAction of the same adipocytes as in (A). (C). Cell signaling, (D) Metabolic, and (E) Immunogenic pathways generated by IPA analysis of MC-seq data (FDR < 0.05).