Table 2.

Associations between BMI at enrollment and prostate cancer in African-American and European-American men

Disease Categories	Casesb/Control	BMI At Enrollmenta			P for trende
		18.5 to <25.0	25.0 to <30.0	30.0 to 50.0
OR (95% CI)c,d
Low-Grade Cancerf
AA	332/474	1 [Reference]	0.91 (0.61 – 1.37)	0.59 (0.39 – 0.91)	0.009
EA	326/534	1 [Reference]	1.52 (1.06 – 2.18)	1.17 (0.78 – 1.77)	0.530
High-Grade Cancerg
AA	70/474	1 [Reference]	0.77 (0.40 – 1.47)	0.45 (0.22 – 0.90)	0.022
EA	70/534	1 [Reference]	1.66 (0.85 – 3.26)	1.38 (0.64 – 2.97)	0.457
Low-Stage Cancerh
AA	353/474	1 [Reference]	0.99 (0.67 – 1.48)	0.65 (0.43 – 0.98)	0.020
EA	337/534	1 [Reference]	1.44 (1.01 – 2.06)	1.24 (0.83 – 1.85)	0.358
High-Stage Canceri
AA	49/474	1 [Reference]	0.48 (0.23 – 1.00)	0.26 (0.12 – 0.59)	0.001
EA	59/534	1 [Reference]	2.14 (1.03 – 4.43)	0.98 (0.41 – 2.38)	0.917
Non-Aggressive Cancerj
AA	307/474	1 [Reference]	0.92 (0.61 – 1.40)	0.62 (0.40 – 0.96)	0.018
EA	293/534	1 [Reference]	1.44 (0.99 – 2.10)	1.21 (0.80 – 1.86)	0.419
Aggressive Cancerk
AA	95/474	1 [Reference]	0.83 (0.47 – 1.48)	0.41 (0.22 – 0.78)	0.004
EA	103/534	1 [Reference]	1.86 (1.06 – 3.26)	1.15 (0.59 – 2.22)	0.758

^aBMI, body mass index (self-reported weight, calculated as weight in kilograms divided by height in meters squared).

^bCases recruited within 1 year after disease diagnosis with an average interval between diagnosis and enrollment of 4.8 months.

^cOR, odds ratio; CI, confidence interval.

^dModels adjusted for age at recruitment, education, diabetes, family history of prostate cancer, and smoking status.

^eP for trend tested with BMI as a continuous variable.

^fGleason score ≤7.

^gGleason score >7.

^hCases pathologically confirmed using AJCC 7th edition T1 or T2.

ⁱCases pathologically confirmed using AJCC 7th edition T3 or T4.

^jCases with pathologically confirmed T1 or T2 and Gleason score ≤7.

^kCases with pathologically confirmed T3 or T4 or Gleason score >7.