Table 5.
Associations between waist circumference and prostate cancer in African-American and European-American men
| Disease Categories | Casesb/Control | Waist circumferencea, cm | P for trende | |||
|---|---|---|---|---|---|---|
|
| ||||||
| 20.8 – 89.9 | 90 – 99.6 | 100 – 109.9 | 110 – 197.8 | |||
| OR (95% CI)c,d | ||||||
| Low-Grade Cancerf | ||||||
| AA | 332/474 | 1 [Reference] | 0.42 (0.27 – 0.66) | 0.67 (0.43 – 1.06) | 0.31 (0.21 – 0.48) | 0.000 |
| EA | 326/534 | 1 [Reference] | 0.42 (0.27 – 0.65) | 0.39 (0.26 – 0.58) | 0.29 (0.19 – 0.45) | 0.000 |
| High-Grade Cancerg | ||||||
| AA | 70/474 | 1 [Reference] | 0.43 (0.20 – 0.95) | 0.61 (0.27 – 1.37) | 0.31 (0.14 – 0.66) | 0.003 |
| EA | 70/534 | 1 [Reference] | 0.49 (0.20 – 1.18) | 0.52 (0.25 – 1.08) | 0.76 (0.39 – 1.46) | 0.257 |
|
| ||||||
| Low-Stage Cancerh | ||||||
| AA | 353/474 | 1 [Reference] | 0.45 (0.29 – 0.69) | 0.68 (0.44 – 1.06) | 0.33 (0.22 – 0.50) | 0.000 |
| EA | 337/534 | 1 [Reference] | 0.40 (0.26 – 0.62) | 0.38 (0.25 – 0.57) | 0.37 (0.25 – 0.56) | 0.000 |
| High-Stage Canceri | ||||||
| AA | 49/474 | 1 [Reference] | 0.29 (0.11 – 0.76) | 0.62 (0.26 – 1.49) | 0.15 (0.05 – 0.44) | 0.001 |
| EA | 59/534 | 1 [Reference] | 0.61 (0.28 – 1.33) | 0.57 (0.27 – 1.18) | 0.29 (0.12 – 0.70) | 0.005 |
|
| ||||||
| Non-Aggressive Cancerj | ||||||
| AA | 307/474 | 1 [Reference] | 0.42 (0.26 – 0.66) | 0.67 (0.42 – 1.06) | 0.32 (0.21 – 0.50) | 0.000 |
| EA | 293/534 | 1 [Reference] | 0.41 (0.26 – 0.65) | 0.39 (0.26 – 0.60) | 0.33 (0.21 – 0.51) | 0.000 |
| Aggressive Cancerk | ||||||
| AA | 95/474 | 1 [Reference] | 0.44 (0.22 – 0.87) | 0.70 (0.35 – 1.39) | 0.28 (0.14 – 0.56) | 0.001 |
| EA | 103/534 | 1 [Reference] | 0.48 (0.24 – 0.94) | 0.47 (0.25 – 0.86) | 0.47 (0.26 – 0.85) | 0.004 |
Waist circumference measured twice at enrollment, average score used. Categories based on Arden et al. 2014.
Cases recruited within 1 year after disease diagnosis with an average interval between diagnosis and enrollment of 4.8 months.
OR, odds ratio; CI, confidence interval.
Models adjusted for age at recruitment, education, diabetes, family history of prostate cancer, and smoking status.
P for trend tested with BMI as a continuous variable.
Gleason score ≤7.
Gleason score >7.
Cases pathologically confirmed using AJCC 7th edition T1 or T2.
Cases pathologically confirmed using AJCC 7th edition T3 or T4.
Cases with pathologically confirmed T1 or T2 and Gleason score ≤7.
Cases with pathologically confirmed T3 or T4 or Gleason score >7.