Table 1. 3D Hits from Primary Screening.

List of the fifteen 3D drug hits identified from the primary drug screen. The disease indication from most drugs was from either inflammation or metabolic disease. The specific target or use for each specific drug as listed from the Selleckchem database. PubMed search results for searching each drug with either “ovarian cancer” (numerator) or “cancer” (denominator) indicates most 3D specific drugs have had limited studies in ovarian cancer.

Drug	Indication	Target or Use	Pub Med Hits
Pizotifen malate	Inflammation	Serotonin antagonist	0/0
Risedronic acid (Actonel)	Metabolic Disease	Osteoporosis drug	0/109
Hydroxyurea (Cytodrox)	Cancer	Free radical nitroxide	43/4234
Pioglitazone hydrochloride (Actos)	Metabolic Disease	Cytochrome P450 (CYP)2C8 and CYP3A4	3/529
Mecarbinate	Metabolic Disease	Antihypertension	0/0
Licofelone	Inflammation	COX/LOX	0/24
OSI-420 (Erlotinib)	Cancer	EGFR	82/5077
Geniposidie	Inflammation	Glucagon-like peptide-1	0/2
Phenformin HCl	Metabolic Disease	Anti-diabetic. Glycolysis	2/129
Cinepazide maleate	Inflammation	Calcium Channel blocker	0/0
Beclomethasone dipropionate	Inflammation	Glucocorticoid	0/60
Dexamethasone acetate	Inflammation	Glucocorticoid	302/14137
Allylthiourea	Inflammation	Ammonia oxidation	0/3
Bergapten	Cancer	DNA mutagen	0/76
Glafenine	Inflammation	NSAID	0/4