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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2018 Jun 4;17(8):1717–1726. doi: 10.1158/1535-7163.MCT-17-1303

Figure 6.

Figure 6

The effect of Selinexor on (A) translational efficiency and (B, C) radioresponse of NSC11-initiated orthotopic xenograft. (A) Mice bearing orthotopic xenografts (40 days after implant, before the onset of morbidity) were treated with vehicle or Selinexor (20mg/kg) by oral gavage. Tumors were collected at the indicated timepoints and polysome profiles generated. Representative profiles from each treatment group are shown; Translational efficiency (TE) values represent the mean ± SEM of 3 mice. Student’s t-test, * p≤0.05, Student’s t-test, Selinexor v. Vehicle. (B) At 24 days after orthotopic implant, mice were randomized and treatment initiated the following day as described in text (IR= 5×2Gy). Kaplan–Meier survival curves were generated with log-rank analysis for comparison. (C) Box plot graph of median survival of each treatment group, * p < 0.05, by Dunnett’s multiple comparison test.