Fig. 2.

Classification results carrier-control model.

Box and scatter plot of each subject's carrier probability score on a scale from 0 (representing control) to 1 (representing presymptomatic FTD mutation carrier) after application of the best performing carrier-control model including the features RD and WMD. Carriers had significantly higher scores than controls (Fig. 2A, p = 0.001). Furthermore, there was an omnibus difference between the four genetic groups (Fig. 2B, p = 0.006), and post-hoc tests revealed higher scores for GRN carriers than for controls (p = 0.009). Abbreviations: C9orf72: chromosome 9 open reading frame 72; GRN: progranulin; MAPT: microtubule-associated protein tau.