Table 1.

Modeled and Measured Sertraline Concentrations in the Plasma of Adult Male Pimephales promelas Following 28-d Aqueous Exposures and Associated Effects Ratio Defined As [Fish_plasma]:C_max

[aqueous] (μg/L)	mean fishplasmaa (μg/L)	effects ratiob
3c	223e	0.64f–0.85g
10c	745e	0.19f–0.26g
30c	2235e	0.06f–0.09g
2.8d	305d	0.47f–0.62g
9.4d	610d	0.23f–0.31g
28.1d	1927d	0.07f–0.10g

^a[Aqueous] × P_blood:water.

^bFish_piasma/C_max.

^cNominal concentration.

^dMeasured concentration.

^eModeled concentration.

^fC_max 142 μg/L (Thomson 2008).

^gC_max 190 μg/L (Product registry).