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. 2018 Aug 3;4:28. doi: 10.1038/s41540-018-0062-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Correlation of PGE2 decrease with pain relief. Predicted decrease in PGE2 formation over time compared with the drug-free treatment is correlated with mean pain relief scores observed in patients after 6 h for a 25 mg, 50 mg, and 100 mg diclofenac, and b 400 mg celecoxib. Placebo effects of both studies are additionally shown. Celecoxib, CEL; diclofenac, DFN; prostaglandin E2, PGE2