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. 2018 Aug 2;8:11588. doi: 10.1038/s41598-018-29331-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NVP-AAM077 and MK-801 induce similar increases in high frequency power, but have different effects on low frequency power. Median (n = 6) spectral power (normalized as a percentage change from mean baseline power) summed over the δ (1–5 Hz), θ (5–11 Hz), high γ (40–90 Hz), and HFO (120–160 Hz) bands are shown for frontal (top), occipital (middle), and CA1 (bottom) electrodes, following saline (left), MK-801 (middle left), NVP-AAM077 (middle right), and Ro25–6985 (right) injection. Stars indicate 6 min periods for which spectral power is significantly higher (above) or lower (below) than saline (ranksum test, significance level = 0.05).