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. 2018 Aug 2;8:11588. doi: 10.1038/s41598-018-29331-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Patterns of phase-amplitude coupling following MK-801 and NVP-AAM077 injection differ markedly. In the left three columns, median (n = 6) comodulograms for the h of largest effect are shown for simultaneous LFP recordings from frontal (top row), occipital (middle row), and CA1 (bottom row) electrodes, following injection of saline, MK-801, and NVP-AAM07. These comodulograms are also shown in Figs 3 and 4 and S1; here they are shown with individually optimized color scales, to more clearly show the pattern of PAC in each region during the h of largest effect for each drug. The right two columns show timeseries of summed PAC over the θ-HFO (red rectangle and time series) and δ-HFO (green rectangle and time series) frequency ranges from 2 h pre-injection to 6 h post-injection. Thick lines are drug time series; thin lines are saline time series; stars indicate 6 min periods for which drug PAC is significantly higher (above) or lower (below) than saline (ranksum test, significance level = 0.05).